S 47445 Produces Antidepressant- and Anxiolytic-Like Effects through Neurogenesis Dependent and Independent Mechanisms

S 47445 Produces Antidepressant- and Anxiolytic-Like Effects through Neurogenesis Dependent and Independent Mechanisms

Glutamatergic dysfunctions are observed in the pathophysiology of depression. The glutamatergic synapse as well as the AMPA receptor’s (AMPAR) activation may represent new potential targets for therapeutic intervention in the context of major depressive disorders. S 47445 is a novel AMPARs positive...

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Bibliographic Details
Main Authors: Indira Mendez-David, Jean-Philippe Guilloux, Mariusz Papp, Laurent Tritschler, Elisabeth Mocaer, Alain M. Gardier, Sylvie Bretin, Denis J. David
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-07-01
Series:Frontiers in Pharmacology
Subjects:
AMPAR
positive allosteric modulator
corticosterone
chronic mild stress
antidepressant
neurogenesis
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00462/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2017.00462/full

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