Transcriptome Responses to Dexamethasone Depending on Dose and Glucocorticoid Receptor Sensitivity in the Liver

Transcriptome Responses to Dexamethasone Depending on Dose and Glucocorticoid Receptor Sensitivity in the Liver

Tissue sensitivity to glucocorticoids is a key factor dictating outcome of their homeostatic and therapeutic action, whereby liver represents one of the major peripheral targets. Here, we used pigs carrying a natural gain-of-function glucocorticoid receptor (GR) variant Ala610Val (GRAla610Val) as a...

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Bibliographic Details
Main Authors: Eduard Murani, Nares Trakooljul, Frieder Hadlich, Siriluck Ponsuksili, Klaus Wimmers
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Genetics
Subjects:
dexamethasone
glucocorticoid receptor
glucocorticoid sensitivity
liver
protocadherin
transcriptome
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2019.00559/full

Internet

https://www.frontiersin.org/article/10.3389/fgene.2019.00559/full

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