Identification of a novel Arg→Cys mutation in the LDL receptor that contributes to spontaneous hypercholesterolemia in pigs

Identification of a novel Arg→Cys mutation in the LDL receptor that contributes to spontaneous hypercholesterolemia in pigs

We previously carried out genetic and metabolic studies in a partially inbred herd of pigs carrying cholesterol-elevating mutations. Quantitative pedigree analysis indicated that apolipoprotein (apo)B and a second major gene were responsible for the hypercholesterolemia in these animals. In this stu...

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Bibliographic Details
Main Authors: Kurt A.A. Grunwald, Kathryn Schueler, Patricia J. Uelmen, Beth A. Lipton, Mary Kaiser, Kimberly Buhman, Alan D. Attie
Format: Article
Language:English
Published: Elsevier 1999-03-01
Series:Journal of Lipid Research
Subjects:
cholesterol
apolipoprotein B
polymorphisms
LDL receptor
pigs
hypercholesterolemia
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520324524

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http://www.sciencedirect.com/science/article/pii/S0022227520324524

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