Emerging function of mTORC2 as a core regulator in glioblastoma: metabolic reprogramming and drug resistance

Emerging function of mTORC2 as a core regulator in glioblastoma: metabolic reprogramming and drug resistance

Glioblastoma (GBM) is one of the most lethal human cancers. Genomic analyses define the molecular architecture of GBM and highlight a central function for mechanistic target of rapamycin (mTOR) signaling. mTOR kinase exists in two multi-protein complexes, namely, mTORC1 and mTORC2. These complexes d...

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Bibliographic Details
Main Authors: Si-Han Wu, Jun-Feng Bi, Timothy Cloughesy, Webster K. Cavenee, Paul S. Mischel
Format: Article
Language:English
Published: China Anti-Cancer Association 2014-12-01
Series:Cancer Biology & Medicine
Subjects:
Glioblastoma
mTOR
metabolic reprogramming
mTORC2
Warburg effect
PI3K
Online Access:http://www.cancerbiomed.org/index.php/cocr/article/view/823

Internet

http://www.cancerbiomed.org/index.php/cocr/article/view/823

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