Turning-off Signaling by Siglecs, Selectins and Galectins: Chemical Inhibition of Glycan-dependent Interactions in Cancer

Aberrant glycosylation, a common feature associated with malignancy, has been implicated in important events during cancer progression. Our understanding of the role of glycans in cancer has grown exponentially in the last few years, concurrent with important advances in glycomics and glycoproteomic...

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Bibliographic Details
Main Authors: Alejandro Javier Cagnoni, Juan Manuel Pérez Sáez, Gabriel Adrián Rabinovich, Karina Valeria Mariño
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-05-01
Series:Frontiers in Oncology
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2016.00109/full