SARS‐CoV‐2 sculpts the immune system to induce sustained virus‐specific naïve‐like and memory B‐cell responses

SARS‐CoV‐2 sculpts the immune system to induce sustained virus‐specific naïve‐like and memory B‐cell responses

Abstract Objectives SARS‐CoV‐2 infection induces virus‐reactive memory B cells expressing unmutated antibodies, which hints at their emergence from naïve B cells. Yet, the dynamics of virus‐specific naïve B cells and their impact on immunity and immunopathology remain unclear. Methods We longitudina...

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Bibliographic Details
Main Authors: Leire de Campos‐Mata, Sonia Tejedor Vaquero, Roser Tachó‐Piñot, Janet Piñero, Emilie K Grasset, Itziar Arrieta Aldea, Natalia Rodrigo Melero, Carlo Carolis, Juan P Horcajada, Andrea Cerutti, Judit Villar‐García, Giuliana Magri
Format: Article
Language:English
Published: Wiley 2021-01-01
Series:Clinical & Translational Immunology
Subjects:
adaptive immunity
antibodies
B‐cell memory
COVID‐19
naïve B cells
Online Access:https://doi.org/10.1002/cti2.1339

Internet

https://doi.org/10.1002/cti2.1339

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