Beneficial Effect of a Selective Adenosine A2A Receptor Antagonist in the APPswe/PS1dE9 Mouse Model of Alzheimer’s Disease

Beneficial Effect of a Selective Adenosine A2A Receptor Antagonist in the APPswe/PS1dE9 Mouse Model of Alzheimer’s Disease

Consumption of caffeine, a non-selective adenosine A2A receptor (A2AR) antagonist, reduces the risk of developing Alzheimer’s disease (AD) and mitigates both amyloid and Tau lesions in transgenic mouse models of the disease. While short-term treatment with A2AR antagonists have been shown to allevia...

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Bibliographic Details
Main Authors: Emilie Faivre, Joana E. Coelho, Katja Zornbach, Enas Malik, Younis Baqi, Marion Schneider, Lucrezia Cellai, Kevin Carvalho, Shéhérazade Sebda, Martin Figeac, Sabiha Eddarkaoui, Raphaëlle Caillierez, Yijuang Chern, Michael Heneka, Nicolas Sergeant, Christa E. Müller, Annett Halle, Luc Buée, Luisa V. Lopes, David Blum
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Alzheimer’s disease
amyloid
adenosine receptor
A2A
memory
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2018.00235/full

Internet

https://www.frontiersin.org/article/10.3389/fnmol.2018.00235/full

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