Site-specific effects of neurosteroids on GABAA receptor activation and desensitization

Site-specific effects of neurosteroids on GABAA receptor activation and desensitization

This study examines how site-specific binding to three identified neurosteroid-binding sites in the α1β3 GABAA receptor (GABAAR) contributes to neurosteroid allosteric modulation. We found that the potentiating neurosteroid, allopregnanolone, but not its inhibitory 3β-epimer epi-allopregnanolone, bi...

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Bibliographic Details
Main Authors: Yusuke Sugasawa, Wayland WL Cheng, John R Bracamontes, Zi-Wei Chen, Lei Wang, Allison L Germann, Spencer R Pierce, Thomas C Senneff, Kathiresan Krishnan, David E Reichert, Douglas F Covey, Gustav Akk, Alex S Evers
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-09-01
Series:eLife
Subjects:
neurosteroids
gabaa receptor
desensitization
radioligand binding
photoaffinity labeling
site-directed mutagenesis
Online Access:https://elifesciences.org/articles/55331

Internet

https://elifesciences.org/articles/55331

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