Age- and stress-associated C. elegans granulins impair lysosomal function and induce a compensatory HLH-30/TFEB transcriptional response.

Age- and stress-associated C. elegans granulins impair lysosomal function and induce a compensatory HLH-30/TFEB transcriptional response.

The progressive failure of protein homeostasis is a hallmark of aging and a common feature in neurodegenerative disease. As the enzymes executing the final stages of autophagy, lysosomal proteases are key contributors to the maintenance of protein homeostasis with age. We previously reported that ex...

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Bibliographic Details
Main Authors: Victoria J Butler, Fuying Gao, Christian I Corrales, Wilian A Cortopassi, Benjamin Caballero, Mihir Vohra, Kaveh Ashrafi, Ana Maria Cuervo, Matthew P Jacobson, Giovanni Coppola, Aimee W Kao
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-08-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1008295

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https://doi.org/10.1371/journal.pgen.1008295

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