The WNT Pathway Is Relevant for the BCR-ABL1-Independent Resistance in Chronic Myeloid Leukemia

The WNT Pathway Is Relevant for the BCR-ABL1-Independent Resistance in Chronic Myeloid Leukemia

Notwithstanding the introduction of Tyrosine Kinase Inhibitors (TKIs) revolutionized the outcome of Chronic Myeloid Leukemia (CML), one third of patients still suspends treatment for failure response. Recent research demonstrated that several BCR/ABL1-independent mechanisms can sustain resistance, b...

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Bibliographic Details
Main Authors: Susanna Grassi, Sara Palumbo, Veronica Mariotti, Diego Liberati, Francesca Guerrini, Elena Ciabatti, Serena Salehzadeh, Claudia Baratè, Serena Balducci, Federica Ricci, Gabriele Buda, Lorenzo Iovino, Francesco Mazziotta, Francesco Ghio, Giacomo Ercolano, Antonello Di Paolo, Antonella Cecchettini, Chiara Baldini, Letizia Mattii, Silvia Pellegrini, Mario Petrini, Sara Galimberti
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Oncology
Subjects:
WNT/β-catenin
PcGs
JAK/STAT
CML
BCR/ABL1-independent resistance
PCA
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.00532/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2019.00532/full

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