TLR4 abrogates the Th1 immune response through IRF1 and IFN-β to prevent immunopathology during L. infantum infection.

TLR4 abrogates the Th1 immune response through IRF1 and IFN-β to prevent immunopathology during L. infantum infection.

A striking feature of human visceral leishmaniasis (VL) is chronic inflammation in the spleen and liver, and VL patients present increased production levels of multiple inflammatory mediators, which contribute to tissue damage and disease severity. Here, we combined an experimental model with the tr...

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Main Authors: Laís Amorim Sacramento, Luciana Benevides, Sandra Regina Maruyama, Lucas Tavares, Kiyoshi Ferreira Fukutani, Marcela Francozo, Tim Sparwasser, Fernando Queiroz Cunha, Roque Pacheco Almeida, João Santana da Silva, Vanessa Carregaro
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-03-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1008435

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https://doi.org/10.1371/journal.ppat.1008435

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