S100A10 Has a Critical Regulatory Function in Mammary Tumor Growth and Metastasis: Insights Using MMTV-PyMT Oncomice and Clinical Patient Sample Analysis

S100A10 Has a Critical Regulatory Function in Mammary Tumor Growth and Metastasis: Insights Using MMTV-PyMT Oncomice and Clinical Patient Sample Analysis

S100A10 (p11) is a plasminogen receptor that regulates cellular plasmin generation by cancer cells. In the current study, we used the MMTV-PyMT mouse breast cancer model, patient tumor microarray, and immunohistochemical (IHC) analysis to investigate the role of p11 in oncogenesis. The genetic delet...

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Bibliographic Details
Main Authors: Alamelu G. Bharadwaj, Margaret L. Dahn, Rong-Zong Liu, Patricia Colp, Lynn N. Thomas, Ryan W. Holloway, Paola A. Marignani, Catherine KL. Too, Penelope J. Barnes, Rosaline Godbout, Paola Marcato, David M. Waisman
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Cancers
Subjects:
breast cancer
S100A10 (p11), tumor growth
tumor progression
macrophages
metastasis
carcinoma
Online Access:https://www.mdpi.com/2072-6694/12/12/3673

Internet

https://www.mdpi.com/2072-6694/12/12/3673

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