Baseline Hedgehog Pathway Activation and Increase of Plasma Wnt1 Protein Are Associated with Resistance to Immune Checkpoint Inhibitors in Advanced Non-Small-Cell Lung Cancer

Baseline Hedgehog Pathway Activation and Increase of Plasma Wnt1 Protein Are Associated with Resistance to Immune Checkpoint Inhibitors in Advanced Non-Small-Cell Lung Cancer

Hedgehog (Hh) and Wingless-type (Wnt) pathways are associated with resistance to immune checkpoint inhibitors (ICIs) in preclinical studies. This study aimed to assess the association between expression and activation levels of Wnt and Sonic Hedgehog (Shh) pathways and resistance to ICIs in advanced...

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Bibliographic Details
Main Authors: Camille Mehlman, Paul Takam Kamga, Adrien Costantini, Catherine Julié, Coraline Dumenil, Jennifer Dumoulin, Julia Ouaknine, Violaine Giraud, Thierry Chinet, Jean-François Emile, Etienne Giroux Leprieur
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Cancers
Subjects:
non-small cell lung cancer
Sonic Hedgehog
Wnt
immune checkpoint inhibitor
resistance
Gli1
Online Access:https://www.mdpi.com/2072-6694/13/5/1107

Internet

https://www.mdpi.com/2072-6694/13/5/1107

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