DGAT1 deficiency decreases PPAR expression and does not lead to lipotoxicity in cardiac and skeletal muscle[S]

DGAT1 deficiency decreases PPAR expression and does not lead to lipotoxicity in cardiac and skeletal muscle[S]

Diacylglycerol (DAG) acyl transferase 1 (Dgat1) knockout (−/−) mice are resistant to high-fat-induced obesity and insulin resistance, but the reasons are unclear. Dgat1−/− mice had reduced mRNA levels of all three Ppar genes and genes involved in fatty acid oxidation in the myocardium of Dgat1−/− mi...

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Bibliographic Details
Main Authors: Li Liu, Shuiqing Yu, Raffay S. Khan, Gene P. Ables, Kalyani G. Bharadwaj, Yunying Hu, Lesley A. Huggins, Jan W. Eriksson, Linda K. Buckett, Andrew V. Turnbull, Henry N. Ginsberg, William S. Blaner, Li-Shin Huang, Ira J. Goldberg
Format: Article
Language:English
Published: Elsevier 2011-04-01
Series:Journal of Lipid Research
Subjects:
heart
triglyceride
diacylglycerol acyl transferase
ceramide
exercise
muscle hypertrophy
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520409071

Internet

http://www.sciencedirect.com/science/article/pii/S0022227520409071

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