Characterizing the PRRSV nsp2 Deubiquitinase Reveals Dispensability of <em>Cis</em>-Activity for Replication and a Link of nsp2 to Inflammation Induction

Characterizing the PRRSV nsp2 Deubiquitinase Reveals Dispensability of <em>Cis</em>-Activity for Replication and a Link of nsp2 to Inflammation Induction

The papain-like cysteine protease 2 (PLP2) within the N-terminus of the porcine reproductive and respiratory syndrome virus (PRRSV) nsp2 replicase protein specifies a deubiquitinating enzyme (DUB), but its biochemical properties and the role in infection have remained poorly defined. By using in vit...

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Bibliographic Details
Main Authors: Shaochuan Zhou, Xinna Ge, Can Kong, Teng Liu, Aijing Liu, Peng Gao, Jiangwei Song, Lei Zhou, Xin Guo, Jun Han, Hanchun Yang
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Viruses
Subjects:
prrsv
deubiquitinase
deubiquitination
<i>trans</i>-cleavage activity
<i>cis</i>-cleavage activity
inflammation
Online Access:https://www.mdpi.com/1999-4915/11/10/896

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https://www.mdpi.com/1999-4915/11/10/896

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