Amyloid-β peptide alteration of tau exon-10 splicing via the GSK3β-SC35 pathway

Amyloid-beta peptide (Aβ) and Tau protein are the lead constituents in the pathogenesis of Alzheimer's disease (AD). However, their inter-relationship in the disease process remains to be established. Tauopathy refers to a characteristic neurodegenerative process in AD. In tauopathy, Tau accumu...

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Bibliographic Details
Main Authors: Kun-Lin Chen, Rey-Yue Yuan, Chaur-Jong Hu, Chung Y. Hsu
Format: Article
Language:English
Published: Elsevier 2010-11-01
Series:Neurobiology of Disease
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996110002093