Protein engineering to develop a redox insensitive endothelial nitric oxide synthase

Protein engineering to develop a redox insensitive endothelial nitric oxide synthase

The zinc tetrathiolate (ZnS4) cluster is an important structural feature of endothelial nitric oxide synthase (eNOS). The cluster is located on the dimeric interface and four cysteine residues (C94 and C99 from two adjacent subunits) form a cluster with a Zn ion in the center of a tetrahedral confi...

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Bibliographic Details
Main Authors: Ruslan Rafikov, Sanjiv Kumar, Saurabh Aggarwal, Daniel Pardo, Fabio V. Fonseca, Jessica Ransom, Olga Rafikova, Qiumei Chen, Matthew L. Springer, Stephen M. Black
Format: Article
Language:English
Published: Elsevier 2014-01-01
Series:Redox Biology
Subjects:
Endothelial nitric oxide synthase
Protein engineering
Redox stability
Zinc tetrathiolate cluster
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231713001031

Internet

http://www.sciencedirect.com/science/article/pii/S2213231713001031

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