Activation of Toll-Like Receptor 9 Impairs Blood Flow Recovery After Hind-Limb Ischemia

Activation of Toll-Like Receptor 9 Impairs Blood Flow Recovery After Hind-Limb Ischemia

Background: Peripheral artery disease causes significant functional disability and results in impaired quality of life. Ischemic tissue injury releases various endogenous ligands for Toll-like receptors (TLRs), suggesting the involvement of TLRs in blood flow recovery. However, the role of TLR9, whi...

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Bibliographic Details
Main Authors: Sachiko Nishimoto, Kunduziayi Aini, Daiju Fukuda, Yasutomi Higashikuni, Kimie Tanaka, Yoichiro Hirata, Shusuke Yagi, Kenya Kusunose, Hirotsugu Yamada, Takeshi Soeki, Michio Shimabukuro, Masataka Sata
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
hind-limb ischemia
blood flow recovery
Toll-like receptor 9
inflammation
macrophage
Online Access:https://www.frontiersin.org/article/10.3389/fcvm.2018.00144/full

Internet

https://www.frontiersin.org/article/10.3389/fcvm.2018.00144/full

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