TNFα induces Ca2+ influx to accelerate extrinsic apoptosis in hepatocellular carcinoma cells

TNFα induces Ca2+ influx to accelerate extrinsic apoptosis in hepatocellular carcinoma cells

Abstract Background Tumor necrosis factor-α has been proven an effective anticancer agent in preclinical studies. However, the translation of TNFα from research to clinic has been blocked by significant systemic toxicity and limited efficacy at maximal tolerated dose, which need urgently to be solve...

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Bibliographic Details
Main Authors: Jianjun Zhu, Mingpeng Jin, Jiaojiao Wang, Hui Zhang, Yousheng Wu, Deyang Li, Xiaoying Ji, Hushan Yang, Chun Yin, Tingting Ren, Jinliang Xing
Format: Article
Language:English
Published: BMC 2018-03-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Cell apoptosis
TNFα
Ca2+ influx
Hepatocellular carcinoma
Online Access:http://link.springer.com/article/10.1186/s13046-018-0714-6

Internet

http://link.springer.com/article/10.1186/s13046-018-0714-6

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