Is age‐related increase of chromosome segregation errors in mammalian oocytes caused by cohesin deterioration?
Abstract Background Mammalian oocytes initiate meiosis in fetal ovary and are arrested at dictyate stage in prophase I for a long period. It is known that incidence of chromosome segregation errors in oocytes increases with advancing age, but the molecular mechanism underlying this phenomenon has no...
Main Author: | |
---|---|
Format: | Article |
Language: | English |
Published: |
Wiley
2020-01-01
|
Series: | Reproductive Medicine and Biology |
Subjects: | |
Online Access: | https://doi.org/10.1002/rmb2.12299 |
id |
doaj-28d8f8878045414b8ae1bf09ae90abbe |
---|---|
record_format |
Article |
spelling |
doaj-28d8f8878045414b8ae1bf09ae90abbe2020-11-25T00:55:17ZengWileyReproductive Medicine and Biology1445-57811447-05782020-01-01191324110.1002/rmb2.12299Is age‐related increase of chromosome segregation errors in mammalian oocytes caused by cohesin deterioration?Jibak Lee0Laboratory of Developmental Biotechnology Graduate School of Agricultural Science Kobe University Kobe JapanAbstract Background Mammalian oocytes initiate meiosis in fetal ovary and are arrested at dictyate stage in prophase I for a long period. It is known that incidence of chromosome segregation errors in oocytes increases with advancing age, but the molecular mechanism underlying this phenomenon has not been clarified. Methods Cohesin, a multi‐subunit protein complex, mediates sister chromatid cohesion in both mitosis and meiosis. In this review, molecular basis of meiotic chromosome cohesion and segregation is summarized. Further, the relationship between chromosome segregation errors and cohesin deterioration in aged oocytes is discussed. Results Recent studies show that chromosome‐associated cohesin decreases in an age‐dependent manner in mouse oocytes. Furthermore, conditional knockout or activation of cohesin in oocytes indicates that only the cohesin expressed before premeiotic S phase can establish and maintain sister chromatic cohesion and that cohesin does not turnover during the dictyate arrest. Conclusion In mice, the accumulating evidence suggests that deterioration of cohesin due to the lack of turnover during dictyate arrest is one of the major causes of chromosome segregation errors in aged oocytes. However, whether the same is true in human remains elusive since even the deterioration of cohesin during dictyate arrest has not been demonstrated in human oocytes.https://doi.org/10.1002/rmb2.12299age‐related aneuploidychromosome segregationcohesionoocytesister chromatid cohesion |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jibak Lee |
spellingShingle |
Jibak Lee Is age‐related increase of chromosome segregation errors in mammalian oocytes caused by cohesin deterioration? Reproductive Medicine and Biology age‐related aneuploidy chromosome segregation cohesion oocyte sister chromatid cohesion |
author_facet |
Jibak Lee |
author_sort |
Jibak Lee |
title |
Is age‐related increase of chromosome segregation errors in mammalian oocytes caused by cohesin deterioration? |
title_short |
Is age‐related increase of chromosome segregation errors in mammalian oocytes caused by cohesin deterioration? |
title_full |
Is age‐related increase of chromosome segregation errors in mammalian oocytes caused by cohesin deterioration? |
title_fullStr |
Is age‐related increase of chromosome segregation errors in mammalian oocytes caused by cohesin deterioration? |
title_full_unstemmed |
Is age‐related increase of chromosome segregation errors in mammalian oocytes caused by cohesin deterioration? |
title_sort |
is age‐related increase of chromosome segregation errors in mammalian oocytes caused by cohesin deterioration? |
publisher |
Wiley |
series |
Reproductive Medicine and Biology |
issn |
1445-5781 1447-0578 |
publishDate |
2020-01-01 |
description |
Abstract Background Mammalian oocytes initiate meiosis in fetal ovary and are arrested at dictyate stage in prophase I for a long period. It is known that incidence of chromosome segregation errors in oocytes increases with advancing age, but the molecular mechanism underlying this phenomenon has not been clarified. Methods Cohesin, a multi‐subunit protein complex, mediates sister chromatid cohesion in both mitosis and meiosis. In this review, molecular basis of meiotic chromosome cohesion and segregation is summarized. Further, the relationship between chromosome segregation errors and cohesin deterioration in aged oocytes is discussed. Results Recent studies show that chromosome‐associated cohesin decreases in an age‐dependent manner in mouse oocytes. Furthermore, conditional knockout or activation of cohesin in oocytes indicates that only the cohesin expressed before premeiotic S phase can establish and maintain sister chromatic cohesion and that cohesin does not turnover during the dictyate arrest. Conclusion In mice, the accumulating evidence suggests that deterioration of cohesin due to the lack of turnover during dictyate arrest is one of the major causes of chromosome segregation errors in aged oocytes. However, whether the same is true in human remains elusive since even the deterioration of cohesin during dictyate arrest has not been demonstrated in human oocytes. |
topic |
age‐related aneuploidy chromosome segregation cohesion oocyte sister chromatid cohesion |
url |
https://doi.org/10.1002/rmb2.12299 |
work_keys_str_mv |
AT jibaklee isagerelatedincreaseofchromosomesegregationerrorsinmammalianoocytescausedbycohesindeterioration |
_version_ |
1725231008504086528 |