A green and facile synthesis of an industrially important quaternary heterocyclic intermediates for baricitinib

A green and facile synthesis of an industrially important quaternary heterocyclic intermediates for baricitinib

Abstract Background Baricitinib, with a 2-(1-(ethylsulfonyl)azetidin-3-yl)acetonitrile moiety at N-2 position of the pyrazol skeleton, is an oral and selective reversible inhibitor of the JAK1 and JAK2 and displays potent anti-inflammatory activity. Several research-scale synthetic methods have been...

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Bibliographic Details
Main Authors: Xin Cui, Junming Du, Zongqing Jia, Xilong Wang, Haiyong Jia
Format: Article
Language:English
Published: BMC 2019-10-01
Series:BMC Chemistry
Subjects:
Baricitinib
JAK1/JAK2 inhibitor
Green synthesis
Microchannel reactor
Online Access:http://link.springer.com/article/10.1186/s13065-019-0639-y

Internet

http://link.springer.com/article/10.1186/s13065-019-0639-y

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