AAV2-mediated delivery of human neurturin to the rat nigrostriatal system: Long-term efficacy and tolerability of CERE-120 for Parkinson’s disease

AAV2-mediated delivery of human neurturin to the rat nigrostriatal system: Long-term efficacy and tolerability of CERE-120 for Parkinson’s disease

Neurturin (NTN) is a neurotrophic factor with known potential to protect and restore the function of dopaminergic substantia nigra neurons whose degeneration has been most closely linked to the major motor deficits in Parkinson’s disease (PD). CERE-120, an adeno-associated virus serotype 2 (AAV2)-ba...

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Bibliographic Details
Main Authors: Mehdi Gasmi, Eugene P. Brandon, Christopher D. Herzog, Alistair Wilson, Kathie M. Bishop, Eva K. Hofer, Justine J. Cunningham, Marie A. Printz, Jeffrey H. Kordower, Raymond T. Bartus
Format: Article
Language:English
Published: Elsevier 2007-07-01
Series:Neurobiology of Disease
Subjects:
Parkinson’s disease
Neurturin
Glial cell line-derived neurotrophic factor
Gene delivery
Adeno-associated virus
6-OHDA lesion
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996107000861

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http://www.sciencedirect.com/science/article/pii/S0969996107000861

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