Hypomethylation in HBV integration regions aids non-invasive surveillance to hepatocellular carcinoma by low-pass genome-wide bisulfite sequencing

Hypomethylation in HBV integration regions aids non-invasive surveillance to hepatocellular carcinoma by low-pass genome-wide bisulfite sequencing

Abstract Background Circulating cell-free DNA (cfDNA) methylation has been demonstrated to be a promising approach for non-invasive cancer diagnosis. However, the high cost of whole genome bisulfite sequencing (WGBS) hinders the clinical implementation of a methylation-based cfDNA early detection bi...

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Bibliographic Details
Main Authors: Haikun Zhang, Peiling Dong, Shicheng Guo, Chengcheng Tao, Wei Chen, Wenmin Zhao, Jiakang Wang, Ramsey Cheung, Augusto Villanueva, Jian Fan, Huiguo Ding, Steven J. Schrodi, Dake Zhang, Changqing Zeng
Format: Article
Language:English
Published: BMC 2020-08-01
Series:BMC Medicine
Subjects:
Cell-free DNA
Hepatocellular carcinoma
HBV integration
Low-pass WGBS
DNA methylation
Online Access:http://link.springer.com/article/10.1186/s12916-020-01667-x

Internet

http://link.springer.com/article/10.1186/s12916-020-01667-x

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