Urothelial bladder cancer may suppress perforin expression in CD8+ T cells by an ICAM-1/TGFβ2 mediated pathway.

Urothelial bladder cancer may suppress perforin expression in CD8+ T cells by an ICAM-1/TGFβ2 mediated pathway.

The immune system plays a significant role in urothelial bladder cancer (UBC) progression, with CD8+ T cells being capable to directly kill tumor cells using perforin and granzymes. However, tumors avoid immune recognition by escape mechanisms. In this study, we aim to demonstrate tumor immune escap...

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Bibliographic Details
Main Authors: Ciputra Adijaya Hartana, Emma Ahlén Bergman, A Ali Zirakzadeh, David Krantz, Malin E Winerdal, Max Winerdal, Markus Johansson, Farhood Alamdari, Tomasz Jakubczyk, Hans Glise, Katrine Riklund, Amir Sherif, Ola Winqvist
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6028111?pdf=render

Internet

http://europepmc.org/articles/PMC6028111?pdf=render

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