N-Glycosylation regulates endothelial lipase-mediated phospholipid hydrolysis in apoE- and apoA-I-containing high density lipoproteins

N-Glycosylation regulates endothelial lipase-mediated phospholipid hydrolysis in apoE- and apoA-I-containing high density lipoproteins

Endothelial lipase (EL) is a member of the triglyceride lipase gene family with high phospholipase and low triacylglycerol lipase activities and a distinct preference for hydrolyzing phospholipids in HDL. EL has five potential N-glycosylation sites, four of which are glycosylated. The aim of this st...

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Bibliographic Details
Main Authors: Danielle Skropeta, Chatri Settasatian, Monica R. McMahon, Kate Shearston, Daniela Caiazza, Kristine C. McGrath, Weijun Jin, Daniel J. Rader, Philip J. Barter, Kerry-Anne Rye
Format: Article
Language:English
Published: Elsevier 2007-09-01
Series:Journal of Lipid Research
Subjects:
N-linked glycans
site-directed mutagenesis
apolipoprotein E
apolipoprotein A-I
phospholipase kinetics
Michaelis-Menten constant
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520424927

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http://www.sciencedirect.com/science/article/pii/S0022227520424927

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