Synthesis, Characterization, and Biologic Activity of New Acyl Hydrazides and 1,3,4-Oxadiazole Derivatives

Synthesis, Characterization, and Biologic Activity of New Acyl Hydrazides and 1,3,4-Oxadiazole Derivatives

Starting from isoniazid and carboxylic acids as precursors, thirteen new hydrazides and 1,3,4-oxadiazoles of 2-(4-substituted-phenoxymethyl)-benzoic acids were synthesized and characterized by appropriate means. Their biological properties were evaluated in terms of apoptosis, cell cycle blocking, a...

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Bibliographic Details
Main Authors: Irina Zarafu, Lilia Matei, Coralia Bleotu, Petre Ionita, Arnaud Tatibouët, Anca Păun, Ioana Nicolau, Anamaria Hanganu, Carmen Limban, Diana Camelia Nuta, Roxana Maria Nemeș, Carmen Cristina Diaconu, Cristiana Radulescu
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Molecules
Subjects:
isoniazid
oxadiazole
synthesis
antibacterial activity
apoptosis
cell cycle
Online Access:https://www.mdpi.com/1420-3049/25/14/3308

Internet

https://www.mdpi.com/1420-3049/25/14/3308

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