Shugoshin 1 is dislocated by KSHV-encoded LANA inducing aneuploidy.

Shugoshin 1 is dislocated by KSHV-encoded LANA inducing aneuploidy.

Shugoshin-1 (Sgo1) protects the integrity of the centromeres, and H2A phosphorylation is critical for this process. The mitotic checkpoint kinase Bub1, phosphorylates H2A and ensures fidelity of chromosome segregation and chromosome number. Oncogenic KSHV induces genetic alterations through chromoso...

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Bibliographic Details
Main Authors: Fengchao Lang, Zhiguo Sun, Yonggang Pei, Rajnish Kumar Singh, Hem Chandra Jha, Erle S Robertson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-09-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC6136811?pdf=render

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http://europepmc.org/articles/PMC6136811?pdf=render

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