Aerosolized In Vivo 3D Localization of Nose-to-Brain Nanocarrier Delivery Using Multimodality Neuroimaging in a Rat Model—Protocol Development

Aerosolized In Vivo 3D Localization of Nose-to-Brain Nanocarrier Delivery Using Multimodality Neuroimaging in a Rat Model—Protocol Development

The fate of intranasal aerosolized radiolabeled polymeric micellar nanoparticles (LPNPs) was tracked with positron emission tomography/computer tomography (PET/CT) imaging in a rat model to measure nose-to-brain delivery. A quantitative temporal and spatial testing protocol for new radio-nanotherano...

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Bibliographic Details
Main Authors: Michael C. Veronesi, Brian D. Graner, Shih-Hsun Cheng, Marta Zamora, Hamideh Zarrinmayeh, Chin-Tu Chen, Sudip K. Das, Michael W. Vannier
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Pharmaceutics
Subjects:
intranasal delivery
positron emission tomography
hybrid nanoparticles
nose to brain delivery
nanotechnology
fate mapping
Online Access:https://www.mdpi.com/1999-4923/13/3/391

Internet

https://www.mdpi.com/1999-4923/13/3/391

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