<i>ETV6</i>/<i>RUNX1</i> Fusion Gene Abrogation Decreases the Oncogenicity of Tumour Cells in a Preclinical Model of Acute Lymphoblastic Leukaemia

<i>ETV6</i>/<i>RUNX1</i> Fusion Gene Abrogation Decreases the Oncogenicity of Tumour Cells in a Preclinical Model of Acute Lymphoblastic Leukaemia

Background: The t(12;21)(p13;q22), which fuses <i>ETV6</i> and <i>RUNX1</i> genes, is the most common genetic abnormality in children with B-cell precursor acute lymphoblastic leukaemia. The implication of the fusion protein in leukemogenesis seems to be clear. However, its r...

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Bibliographic Details
Main Authors: Adrián Montaño, Jose Luis Ordoñez, Verónica Alonso-Pérez, Jesús Hernández-Sánchez, Sandra Santos, Teresa González, Rocío Benito, Ignacio García-Tuñón, Jesús María Hernández-Rivas
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Cells
Subjects:
acute lymphoblastic leukaemia
etv6/runx1
crispr/cas9
genome edition
Online Access:https://www.mdpi.com/2073-4409/9/1/215

Internet

https://www.mdpi.com/2073-4409/9/1/215

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