Aging Impairs Cerebrovascular Reactivity at Preserved Resting Cerebral Arteriolar Tone and Vascular Density in the Laboratory Rat

Aging Impairs Cerebrovascular Reactivity at Preserved Resting Cerebral Arteriolar Tone and Vascular Density in the Laboratory Rat

The age-related (mal)adaptive modifications of the cerebral microvascular system have been implicated in cognitive impairment and worse outcomes after ischemic stroke. The magnitude of the hyperemic response to spreading depolarization (SD), a recognized principle of ischemic lesion development has...

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Bibliographic Details
Main Authors: Armand R. Bálint, Tamás Puskás, Ákos Menyhárt, Gábor Kozák, Imre Szenti, Zoltán Kónya, Tamás Marek, Ferenc Bari, Eszter Farkas
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Aging Neuroscience
Subjects:
aging
cerebral blood flow
cerebral ischemia
neurovascular coupling
arteriolar diameter
reperfusion
Online Access:https://www.frontiersin.org/article/10.3389/fnagi.2019.00301/full

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https://www.frontiersin.org/article/10.3389/fnagi.2019.00301/full

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