Chronic ketamine impairs fear conditioning and produces long-lasting reductions in auditory evoked potentials
Ketamine is an NMDA receptor antagonist with a variety of uses, ranging from recreational drug to pediatric anesthetic and chronic pain reliever. Despite its value in the clinical setting, little is known about the immediate and long-lasting effects of repeated ketamine treatment. We assessed the ef...
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doaj-28f74695b36f4fbca6b3e5bac47ddf2a2021-03-20T04:57:38ZengElsevierNeurobiology of Disease1095-953X2009-08-01352311317Chronic ketamine impairs fear conditioning and produces long-lasting reductions in auditory evoked potentialsLaura C. Amann0Tobias B. Halene1Richard S. Ehrlichman2Stephen N. Luminais3Nan Ma4Ted Abel5Steven J. Siegel6SMRI Laboratory for Experimental Therapeutics in Psychiatry, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USASMRI Laboratory for Experimental Therapeutics in Psychiatry, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA; International Research Training Group 1328 Schizophrenia and Autism, Department of Psychiatry and Psychotherapy, RWTH Aachen University, Aachen, Germany; Transdisciplinary Tobacco Use Research Center, University of Pennsylvania, Philadelphia, PA, USASMRI Laboratory for Experimental Therapeutics in Psychiatry, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USASMRI Laboratory for Experimental Therapeutics in Psychiatry, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USADepartment of Biology, University of Pennsylvania, Philadelphia, PA, USADepartment of Biology, University of Pennsylvania, Philadelphia, PA, USASMRI Laboratory for Experimental Therapeutics in Psychiatry, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA; Transdisciplinary Tobacco Use Research Center, University of Pennsylvania, Philadelphia, PA, USA; Corresponding author. Department of Psychiatry, University of Pennsylvania, Translational Research Laboratories, Rm. 2223, 125 S. 31st Street, Philadelphia, PA 19104, USA. Fax: +1 215 573 2041.Ketamine is an NMDA receptor antagonist with a variety of uses, ranging from recreational drug to pediatric anesthetic and chronic pain reliever. Despite its value in the clinical setting, little is known about the immediate and long-lasting effects of repeated ketamine treatment. We assessed the effects of chronic administration of a subanesthetic dose of ketamine on contextual fear conditioning, detection of pitch deviants and auditory gating. After four, but not two, weeks of daily ketamine injections, mice exhibited decreased freezing in the fear conditioning paradigm. Gating of the P80 component of auditory evoked potentials was also significantly altered by treatment condition, as ketamine caused a significant decrease in S1 amplitude. Additionally, P20 latency was significantly increased as a result of ketamine treatment. Though no interactions were found involving test week, stimulus and treatment condition, these results suggest that repeated ketamine administration impairs fear memory and has lasting effects on encoding of sensory stimuli.http://www.sciencedirect.com/science/article/pii/S0969996109001132KetamineEvent-related potential (ERP)Auditory evoked potential (AEP)GatingFear conditioningSchizophrenia |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Laura C. Amann Tobias B. Halene Richard S. Ehrlichman Stephen N. Luminais Nan Ma Ted Abel Steven J. Siegel |
spellingShingle |
Laura C. Amann Tobias B. Halene Richard S. Ehrlichman Stephen N. Luminais Nan Ma Ted Abel Steven J. Siegel Chronic ketamine impairs fear conditioning and produces long-lasting reductions in auditory evoked potentials Neurobiology of Disease Ketamine Event-related potential (ERP) Auditory evoked potential (AEP) Gating Fear conditioning Schizophrenia |
author_facet |
Laura C. Amann Tobias B. Halene Richard S. Ehrlichman Stephen N. Luminais Nan Ma Ted Abel Steven J. Siegel |
author_sort |
Laura C. Amann |
title |
Chronic ketamine impairs fear conditioning and produces long-lasting reductions in auditory evoked potentials |
title_short |
Chronic ketamine impairs fear conditioning and produces long-lasting reductions in auditory evoked potentials |
title_full |
Chronic ketamine impairs fear conditioning and produces long-lasting reductions in auditory evoked potentials |
title_fullStr |
Chronic ketamine impairs fear conditioning and produces long-lasting reductions in auditory evoked potentials |
title_full_unstemmed |
Chronic ketamine impairs fear conditioning and produces long-lasting reductions in auditory evoked potentials |
title_sort |
chronic ketamine impairs fear conditioning and produces long-lasting reductions in auditory evoked potentials |
publisher |
Elsevier |
series |
Neurobiology of Disease |
issn |
1095-953X |
publishDate |
2009-08-01 |
description |
Ketamine is an NMDA receptor antagonist with a variety of uses, ranging from recreational drug to pediatric anesthetic and chronic pain reliever. Despite its value in the clinical setting, little is known about the immediate and long-lasting effects of repeated ketamine treatment. We assessed the effects of chronic administration of a subanesthetic dose of ketamine on contextual fear conditioning, detection of pitch deviants and auditory gating. After four, but not two, weeks of daily ketamine injections, mice exhibited decreased freezing in the fear conditioning paradigm. Gating of the P80 component of auditory evoked potentials was also significantly altered by treatment condition, as ketamine caused a significant decrease in S1 amplitude. Additionally, P20 latency was significantly increased as a result of ketamine treatment. Though no interactions were found involving test week, stimulus and treatment condition, these results suggest that repeated ketamine administration impairs fear memory and has lasting effects on encoding of sensory stimuli. |
topic |
Ketamine Event-related potential (ERP) Auditory evoked potential (AEP) Gating Fear conditioning Schizophrenia |
url |
http://www.sciencedirect.com/science/article/pii/S0969996109001132 |
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