Brain-derived neurotrophic factor (BDNF) overexpression in the forebrain results in learning and memory impairments

Brain-derived neurotrophic factor (BDNF) overexpression in the forebrain results in learning and memory impairments

In this study we analyzed the effect on behavior of a chronic exposure to brain-derived neurotrophic factor (BDNF), by analysing a mouse line overexpressing BDNF under the αCaMKII promoter, which drives the transgene expression exclusively to principal neurons of the forebrain. BDNF transgenic mice...

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Bibliographic Details
Main Authors: Carla Cunha, Andrea Angelucci, Angela D'Antoni, Mate D. Dobrossy, Stephen B. Dunnett, Nicoletta Berardi, Riccardo Brambilla
Format: Article
Language:English
Published: Elsevier 2009-03-01
Series:Neurobiology of Disease
Subjects:
BDNF
Spatial learning
Passive avoidance
Short-term memory
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996108002775

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http://www.sciencedirect.com/science/article/pii/S0969996108002775

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