Genome-Wide Analysis of Differentially Expressed miRNAs and Their Associated Regulatory Networks in Lenses Deficient for the Congenital Cataract-Linked Tudor Domain Containing Protein TDRD7

Genome-Wide Analysis of Differentially Expressed miRNAs and Their Associated Regulatory Networks in Lenses Deficient for the Congenital Cataract-Linked Tudor Domain Containing Protein TDRD7

Mutations/deficiency of TDRD7, encoding a tudor domain protein involved in post-transcriptional gene expression control, causes early onset cataract in humans. While Tdrd7 is implicated in the control of key lens mRNAs, the impact of Tdrd7 deficiency on microRNAs (miRNAs) and how this contributes to...

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Bibliographic Details
Main Authors: Deepti Anand, Salma Al Saai, Sanjaya K. Shrestha, Carrie E. Barnum, Shinichiro Chuma, Salil A. Lachke
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
cataract
lens aberration
microRNA
microarray
TDRD7
gene regulatory networks
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.615761/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.615761/full

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