Metabolic Vulnerabilities and Epigenetic Dysregulation in Myeloproliferative Neoplasms

Metabolic Vulnerabilities and Epigenetic Dysregulation in Myeloproliferative Neoplasms

The Janus kinase 2 (JAK2)-driven myeloproliferative neoplasms (MPNs) are associated with clonal myelopoiesis, elevated risk of death due to thrombotic complications, and transformation to acute myeloid leukemia (AML). JAK2 inhibitors improve the quality of life for MPN patients, but these approved t...

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Bibliographic Details
Main Authors: Vasundhara Sharma, Kenneth L. Wright, Pearlie K. Epling-Burnette, Gary W. Reuther
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Immunology
Subjects:
myeloproliferative neoplasm
metabolism
epigenetic
EZHZ2
HDAC11
JAK2
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.604142/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.604142/full

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