Targeting MYC dependency in ovarian cancer through inhibition of CDK7 and CDK12/13

Targeting MYC dependency in ovarian cancer through inhibition of CDK7 and CDK12/13

High-grade serous ovarian cancer is characterized by extensive copy number alterations, among which the amplification of MYC oncogene occurs in nearly half of tumors. We demonstrate that ovarian cancer cells highly depend on MYC for maintaining their oncogenic growth, indicating MYC as a therapeutic...

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Bibliographic Details
Main Authors: Mei Zeng, Nicholas P Kwiatkowski, Tinghu Zhang, Behnam Nabet, Mousheng Xu, Yanke Liang, Chunshan Quan, Jinhua Wang, Mingfeng Hao, Sangeetha Palakurthi, Shan Zhou, Qing Zeng, Paul T Kirschmeier, Khyati Meghani, Alan L Leggett, Jun Qi, Geoffrey I Shapiro, Joyce F Liu, Ursula A Matulonis, Charles Y Lin, Panagiotis A Konstantinopoulos, Nathanael S Gray
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-11-01
Series:eLife
Subjects:
ovarian cancer
MYC
THZ1
CDK7
CDK12/13
MCL-1
Online Access:https://elifesciences.org/articles/39030

Internet

https://elifesciences.org/articles/39030

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