Ferroptosis Driver SOCS1 and Suppressor FTH1 Independently Correlate With M1 and M2 Macrophage Infiltration in Head and Neck Squamous Cell Carcinoma

Ferroptosis Driver SOCS1 and Suppressor FTH1 Independently Correlate With M1 and M2 Macrophage Infiltration in Head and Neck Squamous Cell Carcinoma

ObjectiveTo investigate the role of ferroptosis, an iron-dependent form of non-apoptotic cell death, in the head and neck squamous cell carcinoma (HNSCC) immune microenvironment.Materials and MethodsA list of ferroptosis-related genes was obtained from the FerrDb database. Gene expression data were...

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Bibliographic Details
Main Authors: Zhang-Wei Hu, Yi-Hui Wen, Ren-Qiang Ma, Lin Chen, Xue-Lan Zeng, Wei-Ping Wen, Wei Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
ferroptosis
suppressor of cytokine signaling-1
ferritin heavy chain
tumor microenvironment
immune therapy
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.727762/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.727762/full

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