Synthesis and trypanocidal activity of novel pyridinyl-1,3,4-thiadiazole derivatives

Synthesis and trypanocidal activity of novel pyridinyl-1,3,4-thiadiazole derivatives

Herein, we present the design, synthesis and trypanocidal evaluation of sixteen new 1,3,4-thiadiazole derivatives from N-aminobenzyl or N-arylhydrazone series. All derivatives were assayed against the trypomastigote form of Trypanosoma cruzi, showing IC50 values ranging from 3 to 226 μM, and a bette...

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Bibliographic Details
Main Authors: Rosana H.C.N. Freitas, Juliana M.C. Barbosa, Patrícia Bernardino, Vitor Sueth-Santiago, Solange M.S.V. Wardell, James L. Wardell, Débora Decoté-Ricardo, Tatiana G. Melo, Edson F. da Silva, Kelly Salomão, Carlos A.M. Fraga
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Chagas disease
Trypanocidal activity
Inhibitor of sterol biosynthesis
2-amino-1,3,4-thiadiazole
1,3,4-thiadiazole-N-arylhydrazone
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332220303541

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http://www.sciencedirect.com/science/article/pii/S0753332220303541

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