Bmi1 Is Required for Hedgehog Pathway-Driven Medulloblastoma Expansion

Bmi1 Is Required for Hedgehog Pathway-Driven Medulloblastoma Expansion

Inappropriate Hedgehog (Hh) signaling underlies development of a subset of medulloblastomas, and tumors with elevated HH signaling activity express the stem cell self-renewal gene BMI1. To test whether Bmi1 is required for Hh-driven medulloblastoma development, we varied Bmi1 gene dosage in transge...

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Bibliographic Details
Main Authors: Lowell Evan Michael, Bart A. Westerman, Alexandre N. Ermilov, Aiqin Wang, Jennifer Ferris, Jianhong Liu, Marleen Blom, David W. Ellison, Maarten van Lohuizen, Andrzej A. Dlugosz
Format: Article
Language:English
Published: Elsevier 2008-12-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558608800796

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http://www.sciencedirect.com/science/article/pii/S1476558608800796

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