LIN28 Zinc Knuckle Domain Is Required and Sufficient to Induce let-7 Oligouridylation

LIN28 Zinc Knuckle Domain Is Required and Sufficient to Induce let-7 Oligouridylation

LIN28 is an RNA binding protein that plays crucial roles in pluripotency, glucose metabolism, tissue regeneration, and tumorigenesis. LIN28 binds to the let-7 primary and precursor microRNAs through bipartite recognition and induces degradation of let-7 precursors (pre-let-7) by promoting oligouridy...

Full description

Bibliographic Details
Main Authors: Longfei Wang, Yunsun Nam, Anna K. Lee, Chunxiao Yu, Kira Roth, Casandra Chen, Elizabeth M. Ransey, Piotr Sliz
Format: Article
Language:English
Published: Elsevier 2017-03-01
Series:Cell Reports
Subjects:
LIN28
LIN28A
RNA binding protein
let-7
TUTase
TUT4
Zcchc11
oligouridylation
RNA degradation
X-ray structure
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717302425

Internet

http://www.sciencedirect.com/science/article/pii/S2211124717302425

Similar Items