DNA Methylation-Based Interferon Scores Associate With Sub-Phenotypes in Primary Sjögren’s Syndrome

DNA Methylation-Based Interferon Scores Associate With Sub-Phenotypes in Primary Sjögren’s Syndrome

Primary Sjögren’s syndrome (pSS) is an autoimmune inflammatory disease with profound clinical heterogeneity, where excessive activation of the type I interferon (IFN) system is considered one of the key mechanisms in disease pathogenesis. Here we present a DNA methylation-based IFN system activation...

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Bibliographic Details
Main Authors: Juliana Imgenberg-Kreuz, Johanna K. Sandling, Katrine Brække Norheim, Svein Joar Auglænd Johnsen, Roald Omdal, Ann-Christine Syvänen, Elisabet Svenungsson, Lars Rönnblom, Maija-Leena Eloranta, Gunnel Nordmark
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Immunology
Subjects:
primary Sjögren’s syndrome
interferon
DNA methylation
autoimmunity
interferonopathies
precision medicine
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.702037/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.702037/full

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