Polymorphic sites at the immunoregulatory CTLA-4 gene are associated with chronic chagas disease and its clinical manifestations.

Polymorphic sites at the immunoregulatory CTLA-4 gene are associated with chronic chagas disease and its clinical manifestations.

BACKGROUND:Chagas disease affects approximately 10 million people mainly in Latin America. The immune regulation by the host seems to be an essential factor for disease evolution, and immune system inhibitory molecules such as CTLA-4 and PD-1 favor the maintenance of peripheral tolerance. Considerin...

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Bibliographic Details
Main Authors: Fabrício C Dias, Tiago da S Medina, Celso T Mendes-Junior, Roberto O Dantas, Cristina W Pissetti, Virmondes Rodrigues Junior, Renata Dellalibera-Joviliano, José A Marin-Neto, Fredy R S Gutierrez, Philippe Moreau, João S Silva, Eduardo A Donadi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3813449?pdf=render

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http://europepmc.org/articles/PMC3813449?pdf=render

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