The new nitric oxide donor cyclohexane nitrate induces vasorelaxation, hypotension and antihypertensive effects via NO/cGMP/PKG pathway

The new nitric oxide donor cyclohexane nitrate induces vasorelaxation, hypotension and antihypertensive effects via NO/cGMP/PKG pathway

We investigated the cardiovascular effects induced by the nitric oxide donor Cyclohexane Nitrate (HEX). Vasodilatation, NO release and the effects of acute or sub-chronic treatment with HEX on cardiovascular parameters were evaluated. HEX induced endothelium-independent vasodilatation (Maximum effec...

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Bibliographic Details
Main Authors: Leonidas G Mendes-Junior, Drielle Dantas Guimarães, Danilo D Gadelha, Thiago F Diniz, Maria Cláudia R Brandão, Petronio F Athayde-Filho, Virginia S Lemos, Maria Socorro França-Silva, Valdir Andrade Braga
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-08-01
Series:Frontiers in Physiology
Subjects:
Hypertension
KATP Channels
Nitric Oxide
Nitric Oxide Donors
mesenteric artery
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2015.00243/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphys.2015.00243/full

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