Molecular Basis of AmpC β-Lactamase Induction by Avibactam in <i>Pseudomonas aeruginosa</i>: PBP Occupancy, Live Cell Binding Dynamics and Impact on Resistant Clinical Isolates Harboring PDC-X Variants

Molecular Basis of AmpC β-Lactamase Induction by Avibactam in <i>Pseudomonas aeruginosa</i>: PBP Occupancy, Live Cell Binding Dynamics and Impact on Resistant Clinical Isolates Harboring PDC-X Variants

Avibactam belongs to the new class of diazabicyclooctane β-lactamase inhibitors. Its inhibitory spectrum includes class A, C and D enzymes, including <i>P. aeruginosa</i> AmpC. Nonetheless, recent reports have revealed strain-dependent avibactam AmpC induction. In the present work, we wa...

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Bibliographic Details
Main Authors: Silvia López-Argüello, María Montaner, Antonio Oliver, Bartolome Moya
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
penicillin-binding proteins
PBP
avibactam
AmpC induction
PDC
β-lactam resistance
Online Access:https://www.mdpi.com/1422-0067/22/6/3051

Internet

https://www.mdpi.com/1422-0067/22/6/3051

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