Signaling pathways involved in chronic myeloid leukemia pathogenesis: the importance of targeting Musashi2-Numb signaling to eradicate leukemia stem cells

Signaling pathways involved in chronic myeloid leukemia pathogenesis: the importance of targeting Musashi2-Numb signaling to eradicate leukemia stem cells

Objective(s): Chronic myeloid leukemia (CML) is a myeloid clonal proliferation disease defining by the presence of the Philadelphia chromosome that shows the movement of BCR-ABL1. In this study, the critical role of the Musashi2-Numb axis in determining cell fate and relationship of the axis to impo...

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Bibliographic Details
Main Authors: Foruzan Moradi, Sadegh Babashah, Majid Sadeghizadeh, Arsalan Jalili, Abbas Hajifathali, Elham Roshandel
Format: Article
Language:English
Published: Mashhad University of Medical Sciences 2019-06-01
Series:Iranian Journal of Basic Medical Sciences
Subjects:
BCR-ABL1
Chronic myeloid leukemia
Cancer stem cells
Signaling pathways
Self-renewal
Targeted therapy
Online Access:http://ijbms.mums.ac.ir/article_12723_d9b444b5e7550b9883ddcd7802ad293e.pdf

Internet

http://ijbms.mums.ac.ir/article_12723_d9b444b5e7550b9883ddcd7802ad293e.pdf

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