Immunization with virus-like particles conjugated to CIDRα1 domain of Plasmodium falciparum erythrocyte membrane protein 1 induces inhibitory antibodies

Immunization with virus-like particles conjugated to CIDRα1 domain of Plasmodium falciparum erythrocyte membrane protein 1 induces inhibitory antibodies

Abstract Background During the erythrocytic cycle, Plasmodium falciparum malaria parasites express P. falciparum Erythrocyte Membrane Protein 1 (PfEMP1) that anchor the infected erythrocytes (IE) to the vascular lining of the host. The CIDRα1 domain of PfEMP1 is responsible for binding host endothel...

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Bibliographic Details
Main Authors: Charlotte Harmsen, Louise Turner, Susan Thrane, Adam F. Sander, Thor G. Theander, Thomas Lavstsen
Format: Article
Language:English
Published: BMC 2020-03-01
Series:Malaria Journal
Subjects:
Malaria
Plasmodium falciparum
Vaccine
Virus-like particle
Antigenic diversity
PfEMP1
Online Access:http://link.springer.com/article/10.1186/s12936-020-03201-z

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http://link.springer.com/article/10.1186/s12936-020-03201-z

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