Brain intraventricular injection of amyloid-β in zebrafish embryo impairs cognition and increases tau phosphorylation, effects reversed by lithium.

Brain intraventricular injection of amyloid-β in zebrafish embryo impairs cognition and increases tau phosphorylation, effects reversed by lithium.

Alzheimer's disease (AD) is a devastating neurodegenerative disorder with no effective treatment and commonly diagnosed only on late stages. Amyloid-β (Aβ) accumulation and exacerbated tau phosphorylation are molecular hallmarks of AD implicated in cognitive deficits and synaptic and neuronal l...

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Bibliographic Details
Main Authors: Laura Roesler Nery, Natalia Silva Eltz, Cristiana Hackman, Raphaela Fonseca, Stefani Altenhofen, Heydi Noriega Guerra, Vanessa Morais Freitas, Carla Denise Bonan, Monica Ryff Moreira Roca Vianna
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25187954/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25187954/?tool=EBI

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