Edoxaban Exerts Antioxidant Effects Through FXa Inhibition and Direct Radical-Scavenging Activity

Edoxaban Exerts Antioxidant Effects Through FXa Inhibition and Direct Radical-Scavenging Activity

The interplay between oxidative stress, inflammation, and tissue fibrosis leads to the progression of chronic kidney disease (CKD). Edoxaban, an activated blood coagulation factor Xa (FXa) inhibitor, ameliorates kidney disease by suppressing inflammation and tissue fibrosis in animal models. Interes...

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Bibliographic Details
Main Authors: Yuki Narita, Kana Hamamura, Mami Kashiyama, Sara Utsumi, Yutaka Kakizoe, Yuki Kondo, Yoichi Ishitsuka, Hirofumi Jono, Tetsumi Irie, Masashi Mukoyama, Hideyuki Saito, Daisuke Kadowaki, Sumio Hirata, Kenichiro Kitamura
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:International Journal of Molecular Sciences
Subjects:
oxidative stress
reactive oxygen species
antioxidant effect
edoxaban
factor Xa
protease-activated receptor 2
Online Access:https://www.mdpi.com/1422-0067/20/17/4140

Internet

https://www.mdpi.com/1422-0067/20/17/4140

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