Hepatic Stellate Cells and Hepatocarcinogenesis

Hepatic Stellate Cells and Hepatocarcinogenesis

Hepatic stellate cells (HSCs) are a significant component of the hepatocellular carcinoma (HCC) tumor microenvironment (TME). Activated HSCs transform into myofibroblast-like cells to promote fibrosis in response to liver injury or chronic inflammation, leading to cirrhosis and HCC. The hepatic TME...

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Bibliographic Details
Main Authors: Anna E. Barry, Rajkumar Baldeosingh, Ryan Lamm, Keyur Patel, Kai Zhang, Dana A. Dominguez, Kayla J. Kirton, Ashesh P. Shah, Hien Dang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
hepatic stellate cells
hepatocytes
hepatocellular carcinoma
tumor microenvironment
inflammation
fibrosis
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00709/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2020.00709/full

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