HIV Infection Is Associated With Downregulation of BTLA Expression on Mycobacterium tuberculosis-Specific CD4 T Cells in Active Tuberculosis Disease

HIV Infection Is Associated With Downregulation of BTLA Expression on Mycobacterium tuberculosis-Specific CD4 T Cells in Active Tuberculosis Disease

Nearly a quarter of the global population is infected with Mycobacterium tuberculosis (Mtb), with 10 million people developing active tuberculosis (TB) annually. Co-infection with human immunodeficiency virus (HIV) has long been recognized as a significant risk factor for progression to TB disease,...

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Bibliographic Details
Main Authors: Morgan S. Barham, Deborah A. Abrahams, Jeremiah Khayumbi, Joshua Ongalo, Joan Tonui, Angela Campbell, Marwou de Kock, Samuel Gurrion Ouma, Felix Hayara Odhiambo, Willem A. Hanekom, Neel R. Gandhi, Cheryl L. Day
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Immunology
Subjects:
HIV
Mycobacterium tuberculosis
LTBI
active TB disease
CD4 T cell
BTLA
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01983/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01983/full

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