TP53 drives abscopal effect by secretion of senescence-associated molecular signals in non-small cell lung cancer

TP53 drives abscopal effect by secretion of senescence-associated molecular signals in non-small cell lung cancer

Abstract Background Recent developments in abscopal effect strongly support the use of radiotherapy for the treatment of metastatic disease. However, deeper understanding of the molecular mechanisms underlying the abscopal effect are required to best benefit a larger proportion of patients with meta...

Full description

Bibliographic Details
Main Authors: Anna Tesei, Chiara Arienti, Gianluca Bossi, Spartaco Santi, Ilaria De Santis, Alessandro Bevilacqua, Michele Zanoni, Sara Pignatta, Michela Cortesi, Alice Zamagni, Gianluca Storci, Massimiliano Bonafè, Anna Sarnelli, Antonino Romeo, Carola Cavallo, Armando Bartolazzi, Stefania Rossi, Antonella Soriani, Lidia Strigari
Format: Article
Language:English
Published: BMC 2021-03-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Abscopal effect
Non-small cell lung cancer
TP53
Cellular senescence
Extracellular vesicles
DNA:RNA hybrids
Online Access:https://doi.org/10.1186/s13046-021-01883-0

Internet

https://doi.org/10.1186/s13046-021-01883-0

Similar Items